B2B & B2D Market Focus

What experience has the indie community had on providing products with target customers across B2D and B2B? Or frankly across the spectrum of B2B, B2C and B2D? Have been considering adding focus to a project where the data quality focused product has an ideal B2D target market yet could just as easily be used by Marketers/Sales teams with a slick UI. The market is almost exclusively focused on B2E with no love for the long tail in the B2D and B2B space.

Know there are plenty in the camp of find a niche and throw everything at the idea. But want to hear from others that might have found success/failure at providing a niche need product across wider customer groups?